Description
Trade name:
Glyptus
Gliptus
Composition:
Each tablet contains:
Vildagliptin 50 mg
Auxiliary components:
Microcrystalline cellulose, anhydrous lactose, magnesium stearate.
Properties:
Hypoglycemic agent. Vildagliptin is a representative of the class of stimulants of the islet apparatus of the pancreas; it selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). Rapid and complete inhibition of DPP-4 activity (> 90%) causes an increase in both basal and food-stimulated secretion of glucagon-like peptide type 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) from the intestine into the systemic circulation throughout the day.
Indications:
Type 2 diabetes mellitus: as monotherapy in combination with diet therapy and exercise; as part of a two-component combination therapy with metformin, sulfonylurea derivatives, thiazolidinedione or insulin in case of ineffectiveness of diet therapy, exercise and monotherapy with these drugs.
Method of administration and dosage:
The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
The dosage regimen is set individually depending on the efficacy, tolerability and treatment regimen.
Single dose – 50 mg, daily dose – 100 mg (50 mg 2 times / day).
Contraindications:
Hypersensitivity to vildagliptin.
Precautionary measures:
It is not recommended for use in patients with severely impaired liver function, incl. with an increase in ALT or AST activity> 2.5 times higher than ULN.
If jaundice or other signs of liver dysfunction develops, vildagliptin therapy should be discontinued immediately.
If insulin therapy is necessary, vildagliptin is used only in combination with insulin.
Vildagliptin should not be used to treat type 1 diabetes mellitus or to treat diabetic ketoacidosis.
Side effects:
From the digestive system: sometimes – constipation; rarely – dysfunction of the liver (including hepatitis) asymptomatic; when combined with insulin, often – nausea, flatulence, GERD.
From the side of the central nervous system: often – tremor, dizziness, headache.
From the side of metabolism: often – hypoglycemia, weight gain.
Allergic reactions: rarely – angioedema (more often when combined with ACE inhibitors).
Others: often – asthenia, peripheral edema.
Storage method:
Store at a temperature not exceeding 30 degrees.
Package:
The cardboard box contains 3 blisters of 10 tablets, paper instructions.
