Description

Composition:
Each tablet contains:
– Empagliflozin – 10 mg
– Linagliptin – 5 mg
Excipients:
Lactose monohydrate, corn starch, crospovidone, povidone, magnesium stearate, hypromellose, titanium dioxide, etc.
Description:
Glyxambi is a fixed-dose oral combination of empagliflozin (SGLT2 inhibitor) and linagliptin (DPP-4 inhibitor) used to improve glycemic control in adults with type 2 diabetes.
Empagliflozin increases urinary glucose excretion, while linagliptin enhances incretin activity, promotes insulin secretion, and reduces hepatic glucose production.
The medication also reduces cardiovascular mortality in adults with type 2 diabetes and established cardiovascular disease.
Indications for Use:
– Type 2 diabetes mellitus in adults when diet and exercise alone are insufficient.
– Reduction of cardiovascular mortality in adults with type 2 diabetes and established cardiovascular disease (empagliflozin-related benefit).
Not indicated for type 1 diabetes.
Dosage and Method of Administration:
– Recommended dose: 1 tablet (10 mg/5 mg) once daily, in the morning, with or without food.
– Swallow tablets whole.
– Do not discontinue therapy without consulting a healthcare provider.
Contraindications:
– Dialysis.
– Hypersensitivity to empagliflozin, linagliptin or excipients.
– Severe renal impairment (lack of efficacy).
– Type 1 diabetes or diabetic ketoacidosis.
Precautions:
Inform your healthcare provider if you have:
– Pancreatitis or pancreatic surgery;
– Frequent urinary infections;
– Genital infections;
– Dehydration, vomiting, diarrhea;
– Low-carbohydrate or ketogenic diet;
– Alcohol abuse;
– Renal or hepatic impairment;
– Heart failure;
– Upcoming surgery (treatment may need to be paused).
Side Effects:
Very Common:
– Elevated triglyceride levels
– Increased total cholesterol (including LDL cholesterol)
– Decreased hemoglobin
– Decreased HDL cholesterol
– Dizziness
– Somnolence
– Dry mouth
– Headache
– Extrapyramidal symptoms.
Common:
– Vomiting
– Urinary tract infections
– Upper respiratory tract infections
– Hypoglycemia (when used with insulin or sulfonylureas)
– Increased red blood cell count
– Dyspepsia
– Constipation
Seek immediate help if:
– Severe abdominal pain;
– Nausea/vomiting;
– Fruity breath odor, difficulty breathing;
– Swelling of face or throat;
– Redness or swelling in the genital/perineal area.
Pregnancy and Breastfeeding:
– Not recommended during pregnancy.
– Breastfeeding should be discontinued during treatment.
Storage Conditions:
Store below 30°C.
Protect from moisture and light.
Keep out of reach of children.
Packaging:
Carton containing 30 film-coated tablets.