Description
Trade name:
Zovirax
Compound:
Each 5 ml of suspension contains:
Acyclovir 400 mg.
Excipients: Sorbitol 70% solution, glycerin, microcrystalline cellulose and sodium carmellose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, orange flavor, purified water.
Properties:
Acyclovir is an antiviral agent. It has an effect against the Herpes Simplex virus (types 1 and 2), Varicella zoster virus.
Indications:
Treatment of skin and mucous membrane infections caused by Herpes Simplex Virus types 1 and 2, including primary and recurrent genital herpes; prevention of recurrent infections caused by Herpes Simplex Virus types 1 and 2 in patients with normal immune status; prevention of infections caused by Herpes Simplex Virus types 1 and 2 in immunocompromised patients; treatment of primary and recurrent infections caused by Varicella zoster virus – chickenpox and herpes zoster (early treatment of herpes zoster with acyclovir has an analgesic effect and can reduce the incidence of postherpetic neuralgia).
Method of administration and dosage:
By mouth, shake bottle before use. Adults for herpes simplex infection: 200 mg (2.5 ml) 5 times daily every 4 hours, excluding nighttime doses. Duration of treatment is 5 days, but may be extended in severe infections. For immunocompromised patients, the dose is 400 mg (5 ml). Treatment should be started as early as possible, when lesions first appear. Suppression of herpes simplex infections in immunocompromised patients: 200 mg (2.5 ml) 4 times daily at 6-hour intervals. Many patients are prescribed a regimen of 400 mg (5 ml) 2 times daily at 12-hour intervals. Doses up to 200 mg (2.5 ml) 3 times daily at 8-hour intervals, or even 2 times daily at approximately 12-hour intervals, may be effective. Therapy should be interrupted periodically at intervals of 6 to 12 months to observe possible changes in the disease. Prophylaxis of herpes simplex infections in immunocompromised patients: 200 mg (2.5 ml) 4 times daily at approximately 6-hour intervals. In patients with severe immunodeficiency, the dose may be doubled to 400 mg (5 ml). Treatment of chickenpox and herpes simplex: 800 mg (10 ml) 5 times daily at 4-hour intervals, omitting the night doses. Duration: 7 days. Treatment of chickenpox in immunocompetent patients should be started within 24 hours of the onset of the rash. In children for the treatment of herpes simplex infections and prophylaxis of herpes syndrome in immunocompromised patients: Adult doses should be given to children 2 years of age and older, and half the adult dose to children under 2 years of age. Treatment of chickenpox infection in children aged 6 years and above: 800 mg (10 ml) 4 times a day; 2-5 years: 400 mg (5 ml) 4 times a day; under 2 years: 200 mg (5 ml) 4 times a day. Duration of treatment is 5 days. It is recommended to drink more fluids during treatment. For patients with severe renal insufficiency, it is recommended to adjust the dose to 200 mg (2.5 ml) 2 times a day at 12-hour intervals. When treating herpes zoster, it is recommended to adjust the dosage to 800 mg (10 ml) 2 times a day at 12-hour intervals. For patients with severe renal insufficiency – 800 mg (10 ml) 3 times a day at 8-hour intervals for patients with moderate renal insufficiency.
Contraindications:
Hypersensitivity to acyclovir, valacyclovir or any of the other components of the drug. Precautions: for patients with impaired renal function, which is especially common in elderly patients, a lower dose is recommended. In case of impaired renal function, the doctor will adjust the dosage. When using acyclovir, it is necessary to monitor renal function (determination of the level of urea nitrogen in the blood and creatinine in the blood plasma). Drink more fluids while taking acyclovir. When treating genital herpes, you should avoid sexual intercourse or use condoms, since the use of acyclovir does not prevent the transmission of the virus to partners.
Side effects:
Skin rash disappears when the drug is discontinued. Nausea, vomiting, diarrhea, abdominal pain, headache, insomnia, fatigue, dizziness, confusion, hallucinations, and drowsiness have been reported in patients with renal impairment or other conditions. Hepatitis, jaundice, renal colic.
Pregnancy and lactation: Use of acyclovir during pregnancy should be considered only when the potential benefit outweighs the possibility of unknown risks to the mother and fetus. It is excreted in small amounts in breast milk, so caution is recommended when using the drug during breastfeeding.
Storage method:
Store at a temperature not exceeding 30 degrees in a dry place, protected from light and out of reach of children.
Package:
The cardboard box contains a 100 ml bottle and paper instructions.
