Description
Trade name:
Oseltamivir
Compound:
Each capsule contains:
Oseltamivir 75 mg
Auxiliary components:
corn starch, pregelatinized starch, povidone K25, sodium croscarmellose, sodium stearyl fumarate.
Properties:
Antiviral agent. It is a prodrug, the active metabolite (oseltamivir carboxylate) of which selectively inhibits neuraminidase of influenza viruses of types A and B. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between the terminal sialic acid and sugar, thereby facilitating the spread of the virus in the respiratory tract (the release of virions from the infected cell and penetration into the cells of the respiratory tract epithelium, preventing inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside the cells and competitively inhibits neuraminidase of the virus. Inhibits the growth of the influenza virus in vitro and suppresses viral replication and its pathogenicity in vivo. Reduces the excretion of influenza viruses A and B from the body.
Does not affect antibody production in response to inactivated influenza vaccine. The resistance rate of clinical virus isolates is 2%.
Indications:
Influenza types A and B.
Method of administration and dosage:
The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a specific drug with the indications for use and dosage regimen.
Take orally, regardless of food intake.
When treating, it is necessary to start taking the drug no later than 2 days after the onset of symptoms of the disease at a dose of 75 mg 2 times a day for 5 days. Increasing the dose to more than 150 mg/day does not lead to an increase in the effect.
For the prevention of influenza types A and B in adults – 75 mg 1-2 times a day for 6 weeks (during the flu epidemic). The maximum daily dose for adults is 150 mg.
In patients with CC less than 30 ml/min, the dose is reduced to 75 mg once a day for 5 days.
Contraindications:
Chronic renal failure (CC less than 10 ml/min), liver failure, hypersensitivity to oseltamivir.
Precautions:
Use with caution in children.
In patients with hepatic impairment, the safety and efficacy of oseltamivir have not been established.
There are no data on the safety of oseltamivir use with CC less than 10 ml/min.
Side effects:
From the digestive system: nausea, vomiting (usually when taken in high doses, or in the first days of treatment); rarely – diarrhea, abdominal pain.
From the central nervous system: insomnia, dizziness, headache.
From the respiratory system: nasal congestion, sore throat, cough.
Others: feeling tired, weakness.
Storage method:
At a temperature not exceeding 25 degrees. In a dry place.
Package:
The cardboard box contains a blister of 10 capsules and paper instructions.
