Description
Trade name:
Zovirax
Compound:
Each tablet contains:
Acyclovir 400 mg.
Excipients: microcrystalline cellulose, sodium starch gluconate, povidone K30, magnesium stearate, purified water.
Properties:
Acyclovir is an antiviral agent. It has an effect against the Herpes Simplex virus (types 1 and 2), Varicella zoster virus.
Indications:
Treatment of skin and mucous membrane infections caused by Herpes Simplex Virus types 1 and 2, including primary and recurrent genital herpes; prevention of recurrent infections caused by Herpes Simplex Virus types 1 and 2 in patients with normal immune status; prevention of infections caused by Herpes Simplex Virus types 1 and 2 in immunocompromised patients; treatment of primary and recurrent infections caused by Varicella zoster virus – chickenpox and herpes zoster (early treatment of herpes zoster with acyclovir has an analgesic effect and can reduce the incidence of postherpetic neuralgia).
Method of administration and dosage:
Tablets may be dissolved in at least 50 ml of water or swallowed whole with a small amount of water. Adults for herpes simplex infection: 200 mg 5 times daily every 4 hours, excluding nighttime doses. Duration of treatment is 5 days, but may be extended in severe infections. For immunocompromised patients, the dose is 400 mg. Treatment should be started as early as possible, when lesions first appear. Suppression of herpes simplex infections in immunocompromised patients: 200 mg 4 times daily at 6-hour intervals. Many patients are prescribed a regimen of 400 mg twice daily at 12-hour intervals. Doses up to 200 mg, 3 times daily at 8-hour intervals or even 2 times daily at approximately 12-hour intervals, may be effective. Therapy should be interrupted periodically at intervals of 6 to 12 months to observe possible changes in the disease. Prophylaxis of herpes simplex infections in immunocompromised patients: 200 mg 4 times daily at approximately 6-hour intervals. In severely immunocompromised patients, the dose may be doubled to 400 mg. Treatment of chickenpox and herpes simplex: 800 mg 5 times daily at 4-hour intervals, skipping the night doses. Duration: 7 days. Treatment of chickenpox in immunocompetent patients should be started within 24 hours of the onset of the rash. In children, for the treatment of herpes simplex infections and prophylaxis of herpes syndrome in immunocompromised patients: ages 2 years and older should be given the adult dose, and children under 2 years should be given half the adult dose. Treatment of chickenpox infection ages 6 years and older: 800 mg 4 times daily; 2-5 years: 400 mg 4 times daily; Under 2 years: 200 mg 4 times a day. Duration of treatment is 5 days. For patients with severe renal insufficiency, it is recommended to adjust the dose to 200 mg 2 times a day at 12-hour intervals. When treating herpes zoster, it is recommended to adjust the dosage to 800 mg 2 times a day at 12-hour intervals. For patients with severe renal insufficiency – 800 mg 3 times a day at 8-hour intervals for patients with moderate renal insufficiency.
Contraindications:
Hypersensitivity to acyclovir, valacyclovir or any of the other components in the composition, pregnancy and lactation.
Precautions:
For patients with impaired renal function, which is especially common in elderly patients, a lower dose is recommended. If renal function is impaired, the doctor will adjust the dosage. When using acyclovir, renal function should be monitored (determination of the level of urea nitrogen in the blood and creatinine in the blood plasma). Drink more fluids while taking acyclovir. When treating genital herpes, sexual intercourse should be avoided or condoms should be used, since the use of acyclovir does not prevent transmission of the virus to partners.
Side effects:
Skin rash disappears when the drug is discontinued. Nausea, vomiting, diarrhea, abdominal pain, headache, insomnia, fatigue, dizziness, confusion, hallucinations, and drowsiness have been reported in patients with renal impairment or other conditions. Hepatitis, jaundice, renal colic.
Storage method:
Store at a temperature not exceeding 30 degrees in a dry place, protected from light and out of reach of children.
Package:
The cardboard box contains 1 blister of 10 tablets and paper instructions.
