Description
Trade name:
Zithromax
Composition:
Each tablet contains:
Azithromycin 500 mg
Excipients:
Starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, titanium dioxide, lactose, hypromellose, triacetin.
Properties:
A broad-spectrum antibacterial drug from the group of macrolides-azalides, acts bacteriostatically. By binding to the 50S subunit of ribosomes, it inhibits peptide translocase at the translation stage, suppresses protein synthesis, slows the growth and reproduction of bacteria, and has a bactericidal effect in high concentrations. It acts on extra- and intracellular pathogens.
Microorganisms can be initially resistant to the action of the antibiotic or can acquire resistance to it.
Indications:
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
-infections of the upper respiratory tract and ENT organs: pharyngitis, tonsillitis, sinusitis, otitis media;
-infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including those caused by atypical pathogens;
-infections of the skin and soft tissues: acne vulgaris of moderate severity, erysipelas, impetigo, secondarily infected dermatoses;
-initial stage of Lyme disease (borreliosis) – erythema migrans;
-infections of the genitourinary tract caused by Chlamydia trachomatis (urethritis, cervicitis).
Method of administration and dosage:
The drug is taken orally once a day at 500 mg, one hour before meals or two hours after.
Adults (including the elderly) and children over 12 years of age weighing over 45 kg
For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues: 500 mg once a day for 3 days (course dose – 1.5 g).
For migratory erythema: on the first day, 2 tablets of 500 mg at a time, then from the 2nd to the 5th day, 500 mg daily. Course dose is 3.0 g.
For urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis): 2 tablets of 500 mg at a time.
Contraindications:
-severe liver and/or kidney failure;
-children under 12 years of age weighing less than 45 kg (for this dosage form);
-breastfeeding;
-simultaneous administration with ergotamine and dihydroergotamine;
-hypersensitivity to macrolide antibiotics.
Precautions:
If you miss an antibiotic dose, take the missed dose as soon as possible and take subsequent doses at 24-hour intervals.
After discontinuing azithromycin therapy, hypersensitivity reactions may persist for a long time in some patients and may require specific therapy under medical supervision.
Influence on the ability to drive vehicles and operate machinery:
Given the likelihood of developing side effects from the central nervous system, caution should be exercised when driving vehicles and operating machinery.
Side effects:
From the digestive system: nausea, vomiting, diarrhea, abdominal pain, loose stools, flatulence, indigestion, anorexia, constipation.
Allergic reactions: itching, skin rash, angioedema, urticaria, photosensitivity, anaphylactic reaction (in rare cases fatal).
From the cardiovascular system: palpitations, arrhythmia, ventricular tachycardia, prolongation of the QT interval, torsades de pointes.
From the nervous system: dizziness/vertigo, headache, seizures, drowsiness, paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.
From the senses: tinnitus, reversible hearing loss up to deafness (when taking high doses for a long time), impaired perception of taste and smell.
From the circulatory and lymphatic systems: thrombocytopenia, neutropenia, eosinophilia.
From the musculoskeletal system: arthralgia.
From the genitourinary system: interstitial nephritis, acute renal failure.
Others: vaginitis, candidiasis.
Storage method:
Store at a temperature not exceeding 25 degrees.
Packaging:
The cardboard box contains a blister of 3 capsules, paper instructions.
