Description
Tradename:
Trental SR
Compound:
Each tablet contains:
Pentoxifylline 400 mg
Auxiliary components:
Hydroxyethylcellulose, talc, magnesium stearate, sucrose, titanium dioxide, propylene glycol.
Properties:
Vasodilator. Pentoxifylline improves microcirculation and rheological properties of blood. The mechanism of action of pentoxifylline is associated with inhibition of phosphodiesterase and accumulation of cyclic AMP in vascular smooth muscle cells and blood cells. Pentoxifylline inhibits the aggregation of platelets and erythrocytes, increases their elasticity, reduces the level of fibrinogen in plasma and enhances fibrinolysis, which reduces blood viscosity and improves its rheological properties.
Has a weak myotropic vasodilator effect. Pentoxifylline slightly reduces total peripheral resistance and slightly dilates the coronary vessels.
In general, Trental causes an improvement in microcirculation and oxygen supply to tissues in the central nervous system and limbs, and to a lesser extent in the kidneys.
Indications:
– peripheral circulation disorders caused by atherosclerosis, diabetes mellitus (diabetic angiopathy), inflammation;
– acute and chronic disorders of cerebral circulation of ischemic type;
– atherosclerotic and discirculatory encephalopathies;
– angioneuropathy (paresthesia, Raynaud’s disease);
– trophic tissue disorders due to impaired arterial or venous microcirculation (trophic ulcers, postthrombophlebic syndrome, frostbite, gangrene);
– obliterating endarteritis;
-acute, subacute and chronic circulatory failure in the retina or choroid;
– hearing impairment of vascular origin.
Directions for use and dosage:
The duration of treatment and dosage regimen of Trental are determined individually by the attending physician, depending on the clinical picture of the disease and the resulting therapeutic effect.
The drug is taken orally immediately after a meal, without chewing, with a sufficient amount of liquid.
For adults, the drug is prescribed 400 mg 2-3 times a day.
The course of treatment is 2-3 weeks or more.
Contraindications:
-acute myocardial infarction;
-massive bleeding;
– acute hemorrhagic stroke;
– pronounced coronary or cerebral atherosclerosis;
– pronounced heart rhythm disturbances;
– hemorrhages in the retina of the eye;
-pregnancy and breastfeeding;
– age up to 18 years;
– hypersensitivity to pentoxifylline, other methylxanthines or other components of the finished dosage form.
Precautionary measures:
Caution should be exercised when prescribing Trental to patients with peptic ulcers of the stomach and duodenum, or to patients who have recently undergone surgery (risk of bleeding). For patients with labile blood pressure and a tendency to arterial hypotension and patients with severe renal impairment, the dose is increased gradually and selected individually.
Side effects:
Most often, when taking Trental, adverse events from the gastrointestinal tract may occur (nausea, feeling of fullness in the abdomen, stomach cramps, vomiting, diarrhea). Sometimes dizziness and headache may occur. Occasionally, you can observe a decrease in blood pressure, angina pectoris, heart rhythm disturbances, and a feeling of hot flashes.
Storage method:
Store at a temperature not exceeding 25 degrees. In a place protected from light.
