Description
Trade name:
Silden
Compound:
Each tablet contains:
Sildenafil 50 mg
Auxiliary components:
lactose monohydrate (milk sugar), microcrystalline cellulose, sodium croscarmellose, povidone K25, magnesium stearate.
Properties:
A selective inhibitor of cycloguanosine monophosphate (cGMP)-specific PDE5. PDE5, responsible for the breakdown of cGMP, is found not only in the cavernous body of the penis, but also in the vessels of the lungs.
Restores impaired erectile function and provides a natural response to sexual arousal. Sildenafil does not have a direct relaxing effect on the cavernous body, but actively enhances the relaxing effect of nitric oxide on this tissue. During sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body.
Indications:
Treatment of erectile dysfunction characterized by the inability to achieve or maintain an erection of the penis sufficient for satisfactory sexual intercourse.
Pulmonary hypertension.
Method of administration and dosage:
The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a specific drug with the indications for use and dosage regimen.
Treatment of erectile dysfunction: taken orally approximately 1 hour before planned sexual activity. A single dose is 50 mg. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum single dose is 100 mg. The maximum frequency of administration is 1 time per day. For elderly patients over 65 years of age and with concomitant renal or hepatic dysfunction, the dose is 25 mg.
Contraindications:
Concomitant use of nitric oxide donors or nitrates in any form, hypersensitivity to sildenafil.
Precautions:
Before starting to take sildenafil for the treatment of erectile dysfunction, a cardiovascular examination should be performed.
Use with caution in patients with a tendency to bleeding, gastric ulcer and duodenal ulcer in the acute phase, and hereditary retinitis pigmentosa.
Sildenafil is not used in patients under 18 years of age.
Side effects:
From the central nervous system: headache, hot flashes, dizziness, insomnia are possible.
From the digestive system: dyspepsia, asthenia, diarrhea, abdominal pain, nausea are possible.
Storage method:
In a cool, dry place at a temperature not exceeding 30 degrees.
