Description
Trade name:
Sildava
Compound:
Each tablet contains:
Sildenafil 100 mg
Auxiliary components:
Lactose monohydrate, microcrystalline cellulose, povidone, crospovidone, magnesium stearate, aerosil.
Properties:
Sildenafil is a potent, selective inhibitor of cycloguanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Restores impaired erectile function under conditions of sexual stimulation by increasing blood flow in the vessels of the penis.
Indications:
Treatment of erectile dysfunction characterized by the inability to achieve or maintain an erection of the penis sufficient for satisfactory sexual intercourse.
Sildenafil is only effective with sexual stimulation.
Method of administration and dosage:
The drug is taken orally.
For most adult patients, the recommended dose is 50 mg approximately 1 hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg.
The maximum recommended dose is 100 mg. The maximum recommended frequency of use is 1 time per day.
Contraindications:
-severe liver failure;
– severe cardiovascular diseases;
– episodes of development of non-arteritic anterior ischemic optic neuropathy with loss of vision in one eye;
-hereditary retinitis pigmentosa;
– use in patients receiving nitric oxide donors, organic nitrates or nitrites in any form, continuously or intermittently, since sildenafil enhances the hypotensive effect of nitrates;
– concomitant use of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, as this may lead to symptomatic hypotension;
– simultaneous use of the drug with other drugs for the treatment of erectile dysfunction (the safety and effectiveness of combination therapy has not been studied);
– concomitant use of ritonavir;
– lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
– children and adolescents up to 18 years of age;
-use in women;
– hypersensitivity to sildenafil or any other component of the drug.
Precautions:
The drug is prescribed with caution in the following conditions:
anatomical deformation of the penis (angulation, cavernous fibrosis or Peyronie’s disease); diseases predisposing to the development of priapism (sickle cell anemia, multiple myeloma, leukemia, thrombocythemia); diseases accompanied by bleeding; gastric ulcer and duodenal ulcer in the acute phase; liver dysfunction; severe renal failure; an episode of the development of anterior non-arteritic ischemic optic neuropathy in the anamnesis; concomitant use of alpha-blockers.
Side effects:
In fixed-dose studies, the incidence of some adverse events increased with increasing dose. The most common adverse events were: headache, flushing, dizziness, blurred vision, visual impairment, cyanopsia, nasal congestion, nausea, dyspepsia, back pain.
Storage method:
Store at temperatures not exceeding 30 degrees.
