Description
Trade name:
Primperan
Compound:
Each ampoule contains:
Metoclopramide hydrochloride 10.00 mg
Auxiliary components:
Sodium chloride, water for injection.
Properties:
Antiemetic. Specific blocker of dopamine (D2) and serotonin (5-HT3) receptors, inhibits chemoreceptors of the brainstem trigger zone, reduces the sensitivity of visceral nerves transmitting impulses from the pylorus of the stomach and duodenum to the vomiting center.
Indications:
– vomiting, nausea, hiccups of various origins (in some cases it can be effective for vomiting caused by radiation therapy or taking cytostatics);
-atony and hypotension of the stomach and intestines (in particular, postoperative);
– dyskinesia of the biliary tract of the hypomotor type;
-reflux esophagitis;
-flatulence;
-functional pyloric stenosis;
– as part of complex therapy for exacerbations of gastric ulcer and duodenal ulcer;
– used to enhance peristalsis during X-ray contrast studies of the gastrointestinal tract;
– as a means of facilitating duodenal intubation (to speed up the emptying of the stomach and the movement of food through the small intestine).
Method of administration and dosage:
Recommended dose for children aged 1 to 18 years:
0.1 mg-0.15 mg/1 kg of child’s weight 1-2 times a day.
Adults:
10 mg 3 times a day.
The maximum daily dose is 0.5 mg/kg.
The maximum course of treatment is 5 days.
Contraindications:
-bleeding from the gastrointestinal tract;
– pyloric stenosis of the stomach;
– mechanical intestinal obstruction;
-perforation of the stomach or intestinal wall;
– pheochromocytoma;
-epilepsy;
-glaucoma;
– extrapyramidal disorders;
-Parkinson’s disease;
-prolactin-dependent tumors;
– vomiting during treatment or overdose with neuroleptics and in patients with breast cancer;
– bronchial asthma in patients with increased sensitivity to sulfites;
-pregnancy (1st trimester);
– lactation period;
-early childhood;
– hypersensitivity to metoclopramide or any of the components of the drug.
Precautions:
Not effective for vomiting of vestibular origin.
During treatment with the drug, alcohol consumption is not recommended.
Impact on the ability to drive vehicles and operate machinery:
It is recommended to exercise caution when driving a vehicle or working with potentially dangerous machinery that requires increased concentration and quick psychomotor reactions.
Side effects:
From the nervous system: extrapyramidal disorders – spasm of the facial muscles, trismus, rhythmic protrusion of the tongue, bulbar type of speech.
From the digestive system: constipation or diarrhea, rarely – dry mouth.
From the cardiovascular system: atrioventricular block.
From the metabolic side: porphyria.
Allergic reactions: urticaria, bronchospasm, angioedema.
Storage method:
Store at temperatures not exceeding 25 degrees.
Package:
The cardboard box contains 12 ampoules and paper instructions.
