Description
Tradename:
Panadol Migraine
Compound:
Each tablet contains:
Acetaminophen 250 mg
Aspirin 250 mg
Caffeine 65 mg
Auxiliary components:
Hydroxypropyl cellulose, microcrystalline cellulose, stearic acid, povidone, propylene glycol, sorbital monolaurate, titanium dioxide.
Properties:
Panadol Migraine is a combination drug containing acetaminophen (paracetamol), aspirin (acetylsalicylic acid) and caffeine. Paracetamol has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues. Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. Quickly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows down the process of thrombus formation, improving microcirculation at the site of inflammation. Caffeine increases the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, and reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance. In this combination, caffeine in a small dose has virtually no stimulating effect on the central nervous system, but helps to normalize cerebral vascular tone and accelerate blood flow in it.
Indications:
Pain syndrome of moderate and mild intensity of various origins:
headache;
migraine;
toothache;
neuralgia;
arthralgia and myalgia (pain in muscles and joints);
algodismenorrhea (pain during menstruation).
Directions for use and dosage:
The drug is taken orally during or after meals. Adults and adolescents over 15 years of age: 1 tablet every 4-6 hours. At the first sign of migraine, take 2 tablets. The average daily dose is 3-4 tablets per day, the maximum daily dose is 6 tablets per day. After taking 2 tablets, relief from headaches and other types of pain usually occurs quickly – within 15 minutes; for migraines, relief usually occurs within 30 minutes. In case of pain, the drug should not be taken for more than 5 days without consulting a doctor. For migraines, the drug should not be taken for more than 3 days without consulting a doctor.
Contraindications:
hypersensitivity to any of the components in the drug;
erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
gastrointestinal bleeding;
complete or incomplete combination of bronchial asthma, recurrent polypnosis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including a history);
surgical interventions accompanied by bleeding;
hemophilia;
hemorrhagic diathesis;
hypoprothrombinemia;
severe arterial hypertension;
portal hypertension;
severe course of ischemic heart disease;
glaucoma;
vitamin deficiency K;
renal failure;
simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or other non-steroidal anti-inflammatory drug;
deficiency of glucose-6-phosphate dehydrogenase;
pregnancy;
lactation;
increased excitability;
sleep disorders;
children under 15 years of age (risk of developing Reye’s syndrome in children with hyperthermia due to viral diseases).
Use the drug with caution if you have gout, liver disease, headaches associated with head trauma, taking anticoagulants, hypoglycemic agents, gout or arthritis, as well as while taking drugs containing acetylsalicylic acid or other analgesic and antipyretic components.
Precautionary measures:
If symptoms persist, worsen, or new symptoms occur after taking the drug, you should immediately consult a doctor. When taking the drug at the recommended dose, the body receives the same amount of caffeine as is contained in one cup of coffee, so you should reduce the consumption of caffeine-containing products when treating with this drug in order to avoid the development of nervous agitation, irritability, insomnia and rapid heartbeat due to caffeine overdose. If you suspect an overdose, seek immediate medical attention, even if you have no symptoms. You should avoid drinking alcohol while taking the drug due to an increased risk of liver damage and gastrointestinal bleeding. Since acetylsalicylic acid slows down blood clotting, a patient undergoing surgery should notify the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, and therefore in patients with a predisposition, the drug can provoke an attack of gout. With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary.
Side effects:
Gastralgia, nausea, vomiting, hepatotoxin
