Description
Trade name:
Erec
Compound:
Each tablet contains:
Sildenafil 100 mg.
Auxiliary components:
lactose monohydrate (milk sugar), microcrystalline cellulose, sodium croscarmellose, povidone K25, magnesium stearate.
Properties:
A selective inhibitor of cycloguanosine monophosphate (cGMP)-specific PDE5. PDE5, responsible for the breakdown of cGMP, is found not only in the cavernous body of the penis, but also in the vessels of the lungs.
Restores impaired erectile function and provides a natural response to sexual arousal. Sildenafil does not have a direct relaxing effect on the cavernous body, but actively enhances the relaxing effect of nitric oxide on this tissue. During sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body.
As a PDE5 inhibitor, sildenafil increases cGMP levels in pulmonary vascular smooth muscle cells and causes them to relax. In patients with pulmonary hypertension, sildenafil causes pulmonary vasodilation and, to a lesser extent, other vessels.
Indications:
Treatment of erectile dysfunction characterized by the inability to achieve or maintain an erection of the penis sufficient for satisfactory sexual intercourse.
Pulmonary hypertension.
Method of administration and dosage:
Treatment of erectile dysfunction: taken orally approximately 1 hour before planned sexual activity. A single dose is 50 mg. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum single dose is 100 mg. The maximum frequency of administration is 1 time per day. For elderly patients over 65 years of age and with concomitant renal or hepatic dysfunction, the dose is 25 mg.
Pulmonary hypertension: orally 20 mg 3 times a day at intervals of approximately 6-8 hours, regardless of food intake. The maximum daily dose is 60 mg. Patients with impaired renal function do not require dose adjustment, however, if poorly tolerated, the dose is reduced to 20 mg 2 times a day.
Contraindications:
Concomitant use of nitric oxide donors or nitrates in any form, hypersensitivity to sildenafil.
Precautions:
Before starting to take sildenafil for the treatment of erectile dysfunction, a cardiovascular examination should be performed.
It should be used with caution in patients with anatomical deformation of the penis (eg, angulation, cavernosal fibrosis, or Peyronie’s disease) and in people with diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma, or leukemia).
Should not be used in patients for whom sexual activity is undesirable.
Use with caution in patients with a tendency to bleeding, gastric ulcer and duodenal ulcer in the acute phase, and hereditary retinitis pigmentosa.
Sildenafil is not used in patients under 18 years of age.
Side effects:
From the central nervous system: headache, hot flashes, dizziness, insomnia are possible.
From the digestive system: dyspepsia, asthenia, diarrhea, abdominal pain, nausea are possible.
From the musculoskeletal system: arthralgia, myalgia, increased muscle tone.
From the respiratory system: nasal congestion, pharyngitis, rhinitis, sinusitis, respiratory tract infections, respiratory failure.
From the organ of vision: changes in vision (mild and transient; mainly changes in the color of objects, as well as increased perception of light and impaired visual acuity), conjunctivitis.
Storage method:
At a temperature not exceeding 30 degrees.
Package:
The cardboard box contains 3 blisters of 4 tablets and paper instructions.
