Description
Trade name:
Coloverin SR
Compound:
Each capsule contains:
Mebeverine hydrochloride 200 mg
Properties:
A myotropic antispasmodic, it has a direct effect on the smooth muscles of the gastrointestinal tract without affecting normal intestinal motility. The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, norepinephrine reuptake blockade, local anesthetic effect, and changes in water absorption may cause the local action of mebeverine on the gastrointestinal tract. Through these mechanisms, mebeverine exerts an antispasmodic effect, normalizing intestinal motility and without causing permanent relaxation of gastrointestinal smooth muscle cells (“hypotension”).
Indications:
Symptomatic treatment of pain, spasms, dysfunction and discomfort in the intestinal area associated with irritable bowel syndrome (symptoms may include abdominal pain, spasms, a feeling of bloating and flatulence, changes in stool frequency (diarrhea, constipation or alternating diarrhea and constipation), changes in stool consistency).
Method of administration and dosage:
1 capsule 2 times a day. The dose can be increased to 3 capsules per day.
Contraindications:
Hypersensitivity to mebeverine; age under 18 years; pregnancy, breastfeeding.
Precautions:
Before starting to use mebeverine, the patient should consult a doctor in the following cases: if symptoms of the disease have appeared for the first time; in case of unintentional and unexplained weight loss; in case of anemia; in case of rectal bleeding or blood in the stool; in case of fever; in case of a family history of colon cancer, celiac disease or inflammatory bowel disease; in case of the patient over 50 years of age and if symptoms of the disease have appeared for the first time; in case of recent use of antibiotics.
Side effects:
From the skin and subcutaneous tissues: urticaria (allergic rash), angioedema (a serious allergic reaction that may include: difficulty breathing, swelling of the face, neck, lips, tongue, throat), swelling of the face, exanthema (skin rash).
From the immune system: hypersensitivity reactions (anaphylactic reactions – serious allergic reactions that may include difficulty breathing, rapid pulse, a sharp decrease in blood pressure (weakness and dizziness), increased sweating).
Storage method:
At a temperature not exceeding 30 degrees.
Package:
The cardboard box contains 3 blisters of 10 capsules and paper instructions.
