Description
Trade name:
Coloverin D
Compound:
Each tablet contains:
Mebeverine hydrochloride 135 mg
Dimethicone 40 mg
Properties:
Mebeverine hydrochloride is a myotropic antispasmodic agent that acts directly on the smooth muscles of the gastrointestinal tract without affecting normal intestinal motility. The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, norepinephrine reuptake blockade, local anesthetic action, and changes in water absorption, may cause the local action of mebeverine on the gastrointestinal tract. Through these mechanisms, mebeverine exerts an antispasmodic effect, normalizing intestinal motility and without causing permanent relaxation of gastrointestinal smooth muscle cells (“hypotension”).
Dimethicone – reduces gas formation in the intestines, accelerates motility, exhibits foam-extinguishing activity. It is not absorbed from the intestines, has no systemic effect. When applied locally, it has a lubricating effect, gives teeth an even shine and prevents the formation of acid plaque and tartar. It is the basis for some external use products, a component of various cosmetic moisturizing creams and lipodermal complexes (participates in the formation of a protective film), and is part of a number of combination drugs.
Indications:
Treatment of functional bowel disorders such as:
– Irritable bowel syndrome.
– Pain in the abdominal area.
– Flatulence.
– Bloating and dyspepsia.
– Postoperative pain associated with increased gas formation.
Method of administration and dosage:
One tablet 3 or 4 times a day, preferably 30 minutes before meals.
Contraindications:
Hypersensitivity to the components of the drug.
Precautions:
Before starting to use mebeverine, the patient should consult a doctor in the following cases: if symptoms of the disease have appeared for the first time; in case of unintentional and unexplained weight loss; in case of anemia; in case of rectal bleeding or blood in the stool; in case of fever; in case of a family history of colon cancer, celiac disease or inflammatory bowel disease; in case of the patient over 50 years of age and if symptoms of the disease have appeared for the first time; in case of recent use of antibiotics.
Side effects:
From the skin and subcutaneous tissues: urticaria (allergic rash), angioedema (a serious allergic reaction that may include: difficulty breathing, swelling of the face, neck, lips, tongue, throat), swelling of the face, exanthema (skin rash).
From the immune system: hypersensitivity reactions (anaphylactic reactions – serious allergic reactions that may include difficulty breathing, rapid pulse, a sharp decrease in blood pressure (weakness and dizziness), increased sweating).
Storage method:
Store at a temperature not exceeding 30 degrees. In a dry place.
Package:
The cardboard box contains 3 blisters of 10 tablets and paper instructions.
