Description
Trade name:
Colovatil
Compound:
Each tablet contains:
Sulpiride 25 mg
Mebeverine hydrochloride 100 mg
Auxiliary components:
Microcrystalline cellulose, lactose anhydrous, talc, magnesium stearate, titanium dioxide.
Properties:
Mebeverine is a myotropic antispasmodic agent that acts directly on the smooth muscles of the gastrointestinal tract without affecting normal intestinal motility. The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, norepinephrine reuptake blockade, local anesthetic action, and changes in water absorption, may cause the local action of mebeverine on the gastrointestinal tract. Through these mechanisms, mebeverine exerts an antispasmodic effect, normalizing intestinal motility and without causing permanent relaxation of gastrointestinal smooth muscle cells (“hypotension”).
Sulpiride has moderate neuroleptic activity in combination with stimulating and thymoanaleptic (antidepressant) action. The neuroleptic effect is associated with antidopaminergic action. In the central nervous system, sulpiride blocks predominantly dopaminergic receptors of the limbic system, and has little effect on the neostriatal system, it has an antipsychotic effect and causes a small number of side effects. The peripheral action of sulpiride is based on the inhibition of presynaptic receptors. An increase in the amount of dopamine in the central nervous system is associated with an improvement in mood, and a decrease in it is associated with the development of symptoms of depression.
Indications:
Functional gastrointestinal disorder.
Gastrointestinal colic (intestinal, biliary).
Irritable bowel syndrome.
Diverticular diseases.
Post-dysenteric colitis.
Control of gastrointestinal manifestations accompanying psychogenic and migraine headaches.
Method of administration and dosage:
Take 1 tablet 3 times daily.
Contraindications:
Hypersensitivity to mebeverine or sulpride, mental disorders, age under 18 years; pregnancy, breastfeeding.
Precautions:
Before starting to use the drug, the patient should consult a doctor in the following cases: if symptoms of the disease have appeared for the first time; in case of unintentional and unexplained weight loss; in case of anemia; in case of rectal bleeding or blood in the stool; in case of fever; if colon cancer, celiac disease or inflammatory bowel disease have been diagnosed in the patient’s family; if the patient is over 50 years old and if symptoms of the disease have appeared for the first time; in case of recent use of antibiotics.
Side effects:
From the skin and subcutaneous tissues: urticaria (allergic rash), angioedema (a serious allergic reaction that may include: difficulty breathing, swelling of the face, neck, lips, tongue, throat), swelling of the face, exanthema (skin rash).
From the immune system: hypersensitivity reactions (anaphylactic reactions – serious allergic reactions that may include difficulty breathing, rapid pulse, a sharp decrease in blood pressure (weakness and dizziness), increased sweating).
Drowsiness and confusion may also occur.
Storage method:
At a temperature not exceeding 30 degrees. In a dry place.
Package:
The cardboard box contains 3 blisters of 10 tablets and paper instructions.
