Description
Trade name:
Augmentin ES
Composition:
Each 5 ml of the finished suspension contains:
Amoxicillin 652.78 mg
Clavulanic acid 50.41 mg
Excipients:
colloidal silicon dioxide, succinic acid, hypromellose, xanthan gum, strawberry flavor, aspartame.
Properties:
A combination drug of amoxicillin and clavulanic acid – a beta-lactamase inhibitor. It has a bactericidal effect, inhibits the synthesis of the bacterial wall.
Active against aerobic gram-positive bacteria (including strains producing beta-lactamases): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis. The following pathogens are sensitive only in vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; and aerobic gram-negative bacteria (including beta-lactamase-producing strains): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus ducreyi, Yersinia multocida (formerly Pasteurella), Campylobacter jejuni; anaerobic gram-negative bacteria (including beta-lactamase-producing strains): Bacteroides spp., including Bacteroides fragilis.
Clavulanic acid inhibits beta-lactamases types II, III, IV and V, is not active against beta-lactamases type I produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic breakdown of amoxicillin by beta-lactamases.
Indications:
Treatment of infectious and inflammatory diseases caused by sensitive pathogens: lower respiratory tract infections (bronchitis, pneumonia, pleural empyema, lung abscess); ENT infections (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvic peritonitis, chancroid, gonorrhea); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections. Prevention of infections in surgery.
Method of administration and dosage:
Children under 12 years old – in the form of a suspension, syrup or drops for oral administration. A single dose is established depending on age:
Children from 3 months and older – for mild infections – 45 mg / kg / day in 2 doses. The course of treatment is up to 10 days.
8 kg – 3.0 ml 2 times a day;
12 kg – 4.5 ml 2 times a day;
17 kg – 6.0 ml 2 times a day;
20 kg – 7.5 ml 2 times a day;
24 kg – 9.0 ml 2 times a day;
28 kg – 10.5 ml 2 times a day;
32 kg – 12.0 ml 2 times a day;
36 kg – 13.5 ml 2 times a day.
Contraindications:
Hypersensitivity to the components of the drug (including cephalosporins and other beta-lactam antibiotics); infectious mononucleosis (including the appearance of measles-like rash); phenylketonuria; episodes of jaundice or liver dysfunction due to the use of amoxicillin / clavulanic acid in the anamnesis; CC less than 30 ml/min (for tablets 875 mg/125 mg).
With caution:
Pregnancy, lactation, severe liver failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins), chronic renal failure.
Precautions:
During the course of treatment, it is necessary to monitor the function of the hematopoietic organs, liver and kidneys.
In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken during meals.
Superinfection may develop due to the growth of insensitive microflora, which requires an appropriate change in antibacterial therapy.
May give false-positive results when determining glucose in urine. In this case, it is recommended to use the glucose oxidant method for determining the concentration of glucose in urine.
In patients with increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.
Side effects:
From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of liver transaminases, in isolated cases – cholestatic jaundice, hepatitis, liver failure (more often in the elderly, men, with long-term therapy), pseudomembranous and hemorrhagic colitis (may also develop after therapy), enterocolitis, black “hairy” tongue, darkening of tooth enamel.
From the hematopoietic organs: reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.
From the nervous system: dizziness, headache, hyperactivity, anxiety, behavioral changes, convulsions.
Local reactions: in isolated cases – phlebitis at the site of intravenous administration.
Allergic reactions: urticaria, erythematous rash, rarely – erythema multiforme exudative, anaphylactic shock, angioedema, very rarely – exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), allergic vasculitis, serum sickness-like syndrome, acute generalized exanthematous pustulosis.
Others: candidiasis, development of superinfection, interstitial nephritis, crystalluria, hematuria.
Storage method:
At a temperature not exceeding 30 degrees. After opening and dilution, store in the refrigerator and use within 10 days.
Packaging:
A cardboard box contains powder for the preparation of 75 ml of suspension, paper instructions.
