Description
Trade name:
Salofalk
Compound:
Each tablet contains:
Mesalazine 500 mg
Properties:
Mesalazine inhibits the activity of neutrophil lipoxygenase and the synthesis of arachidonic acid metabolites (prostaglandins and leukotrienes), which are inflammatory mediators. It inhibits the migration, degranulation, phagocytosis of neutrophils, as well as the secretion of immunoglobulins by lymphocytes. Mesalazine has antioxidant properties, binding to free oxygen radicals.
Indications:
Non-specific ulcerative colitis (treatment of exacerbations and maintenance therapy in the remission phase); Crohn’s disease (mild and moderate forms in the exacerbation phase); rheumatoid arthritis; juvenile rheumatoid arthritis.
Method of administration and dosage:
Take 1 tablet 3 times daily after meals.
Contraindications:
Porphyria, anemia, severe liver dysfunction, severe renal dysfunction, glucose-6-phosphate dehydrogenase deficiency, children under 5 years of age, lactation period; hypersensitivity to sulfonamides and salicylic acid derivatives.
Precautions:
Use with caution in patients with impaired liver and/or kidney function, patients with bronchial asthma, allergic reactions.
During the treatment period, it is recommended to drink increased amounts of fluid.
During treatment, the level of liver enzymes, complete blood count and urine tests should be monitored.
Side effects:
From the nervous system: headache, dizziness, tinnitus, ataxia, convulsions, sleep disorders, hallucinations, peripheral neuropathy.
From the urinary system: renal dysfunction, interstitial nephritis.
From the digestive system: nausea, vomiting, diarrhea, abdominal pain, anorexia, hepatitis, pancreatitis.
From the respiratory system: interstitial pneumonitis and other lung tissue lesions.
From the hematopoietic system: anemia, leukopenia, thrombocytopenia, agranulocytosis.
From the reproductive system: transient oligospermia, infertility.
Allergic reactions: skin rash, toxic epidermal necrolysis, malignant exudative erythema, fever, anaphylactic shock.
Others: possible yellowing of skin, urine, soft contact lenses.
Storage method:
At a temperature not exceeding 30 degrees.
Package:
The cardboard box contains 2 blisters of 10 tablets and paper instructions.
