Description

Trade name:

Nexium

Compound:

Each tablet contains:

Esomeprazole 40 mg.

Properties:

Esomeprazole is a proton pump inhibitor, is the S-isomer of omeprazole and reduces the secretion of gastric acid.

Indications:

Treatment of gastroesophageal reflux disease (GERD); short-term treatment (4 to 8 weeks) of erosive esophagitis, GERD symptoms (heartburn, etc.). Maintenance therapy of symptoms and healing of erosive esophagitis for no more than 6 months. Treatment of patients with Helicobacter pylori infection and duodenal ulcer. Zollinger-Ellison syndrome. Patients requiring long-term NSAID therapy – healing of gastric ulcers, prevention of gastric and duodenal ulcers associated with NSAID therapy.

Method of administration and dosage:

Adults and adolescents aged 12 years and over should swallow tablets whole with half a glass of water, with food or on an empty stomach. Gastroesophageal reflux disease (GERD) – treatment: 40 mg once a day for 4 weeks. To prevent relapse, symptomatic treatment of GERD – 20 mg once a day. Maintenance therapy: 20 mg once a day.

Adults, in combination with antibacterial drugs to destroy Helicobacter pylori, prevention of recurrence of peptic ulcer in patients with ulcer diseases: 20 mg esomeprazole with 1 g amoxicillin and 500 mg clarithromycin, 2 times a day, for 7 days. Healing of gastric ulcers associated with NSAID therapy: 20 mg once a day. Duration of treatment is 4-8 weeks. Prevention of gastric ulcer and duodenal ulcer associated with NSAID therapy: 20 mg once a day.

Zollinger-Ellison syndrome: Initial dose 40 mg twice daily. Thereafter, the dose should be titrated individually and treatment continued as long as clinically indicated. Most patients can be controlled at doses of 80-160 mg daily, in 2 divided doses.

For patients with severe hepatic impairment: the maximum dose of esomeprazole is 20 mg.

Contraindications:

Children under 12 years of age; hypersensitivity to esomeprazole or any other components of the drug; pregnancy and lactation.

Precautions:

Proton pump inhibitor (PPI) therapy may be associated with an increased risk of osteoporosis-related hip, wrist, or spine fractures with long-term, high-dose therapy.

Side effects:

Headache, dizziness, diarrhea, flatulence, abdominal pain, nausea, constipation, skin reactions (flushing, itching), burning/tingling/numbness, drowsiness, dry mouth, swelling of hands and feet, increased liver enzymes, blurred vision, depression, irritability, confusion, taste disturbance, hair loss, joint and muscle pain, excessive sweating.