Description
Trade name:
Terbin
Compound:
Each gram of cream contains:
Terbinafine hydrochloride 1%
Properties:
An antifungal drug for topical use with a broad spectrum of antifungal activity. Even in low concentrations, terbinafine has a fungicidal effect on dermatophytes (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), molds (mainly C. albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic.
Terbinafine specifically alters the early stage of sterol biosynthesis occurring in fungi. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine acts by inhibiting the enzyme squalene epoxidase, which is located on the fungal cell membrane.
Terbinafine does not affect the human cytochrome P450 system and, accordingly, the metabolism of hormones or other drugs.
Indications:
– prevention and treatment of fungus, fungal skin infections, including mycosis of the feet (foot fungus), inguinal epidermophytosis (tinea cruris), fungal infections of the smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum;
-yeast infections of the skin, mainly those caused by the genus Candida (eg Candida albicans), in particular diaper rash;
– Pityriasis versicolor, caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Method of administration and dosage:
Adults and children over 12 years old:
Before applying the cream, it is necessary to clean and dry the affected areas. The cream is applied once or twice a day in a thin layer to the affected skin and adjacent areas and lightly rubbed in. In case of infections accompanied by diaper rash (under the mammary glands, in the spaces between the fingers, between the buttocks, in the groin area), the areas where the cream is applied can be covered with gauze, especially at night.
Average duration of treatment: dermatomycosis of the trunk, shins – 1 week, 1 time per day; dermatomycosis of the feet – 1 week, 1 time per day; skin candidiasis – 1-2 weeks, 1 or 2 times per day; versicolor lichen: 2 weeks, 1 or 2 times per day.
Contraindications:
– hypersensitivity to terbinafine or to any of the inactive ingredients included in the drug.
With caution: liver and/or kidney failure, alcoholism, suppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive diseases of the vessels of the extremities, children under 12 years of age (lack of sufficient clinical experience).
Precautions:
A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. In case of irregular treatment or its premature termination, there is a risk of relapse of the infection.
Terbin cream is intended for external use only. Avoid contact with eyes, as it may cause irritation. If the preparation accidentally gets into the eyes, they should be immediately rinsed with running water, and if persistent irritation develops, consult a doctor.
If allergic reactions develop, the drug must be discontinued.
Side effects:
Redness, itching or burning may occur at the site of application. Allergic reactions.
Storage method:
At a temperature not exceeding 25 degrees. In a dry place.
Package:
The cardboard box contains a 15 g tube and paper instructions.
