Description
Trade name:
Lamisil
Compound:
Each gram of cream contains:
Terbinafine hydrochloride 10 mg
Auxiliary components:
benzyl alcohol, polysorbate 60 (tween 60), sorbitan monostearate, cetyl alcohol, isopropyl myristate, cetyl palmitate, sodium hydroxide, purified water.
Properties:
An antifungal drug for topical use with a broad spectrum of antifungal activity. Even in low concentrations, terbinafine has a fungicidal effect on dermatophytes (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), molds (mainly C. albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic.
Terbinafine specifically alters the early stage of sterol biosynthesis occurring in fungi. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine acts by inhibiting the enzyme squalene epoxidase, which is located on the fungal cell membrane.
Indications:
– prevention and treatment of fungus, fungal skin infections, including mycosis of the feet (foot fungus), inguinal epidermophytosis (tinea cruris), fungal infections of the smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum;
-yeast infections of the skin, mainly those caused by the genus Candida (eg Candida albicans), in particular diaper rash;
– Pityriasis versicolor, caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Method of administration and dosage:
Externally.
Adults and children over 12 years old:
Before applying the cream, it is necessary to clean and dry the affected areas. Apply the cream once or twice a day in a thin layer to the affected skin and adjacent areas and rub in lightly. In case of infections accompanied by diaper rash (under the mammary glands, in the spaces between the fingers, between the buttocks, in the groin area), the areas where the cream is applied can be covered with gauze, especially at night. Average duration of treatment: dermatomycosis of the trunk, shins – 1 week, once a day; dermatomycosis of the feet – 1 week, once a day; skin candidiasis – 1-2 weeks, 1 or 2 times a day; versicolor lichen: 2 weeks, 1 or 2 times a day.
Contraindications:
– hypersensitivity to terbinafine or to any of the inactive ingredients included in the drug.
With caution: liver and/or kidney failure, alcoholism, suppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive diseases of the vessels of the extremities, children under 12 years of age (lack of sufficient clinical experience).
Precautions:
A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. In case of irregular treatment or its premature termination, there is a risk of relapse of the infection.
Lamisil cream is for external use only. Avoid contact with eyes as it may cause irritation. If the product accidentally gets into eyes, rinse them immediately with running water, and if persistent irritation occurs, consult a doctor.
If allergic reactions develop, the drug must be discontinued.
Side effects:
Redness, itching or burning may occur at the site of application. Allergic reactions.
Storage method:
Store at temperatures not exceeding 30 degrees.
Package:
The cardboard box contains a 15 gram tube and paper instructions.
