Description
Trade name:
Isopto Maxitrol
Compound:
Each 1 ml of solution contains:
Dexamethasone 1 mg
Polymyxin B 6000 IU
Neomycin 3.5 mg
Auxiliary components:
Hydroxypropyl methylcellulose, sodium benzalkonium, disodium edetate, sodium chloride, polysorbate, sodium hydroxide, water for injection.
Properties:
A combination drug for local use in ophthalmology.
Neomycin has a bactericidal effect by disrupting bacterial cell protein synthesis. It is active against Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus viridans, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes and Haemophilus influenzae.
The mechanism of action of polymyxin B is mainly due to the blockade of the permeability of the cytoplasmic membrane of bacterial cells. It is active against Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Koch-Weeks bacillus.
Dexamethasone is a glucocorticosteroid. It has anti-inflammatory, antiallergic and desensitizing effects. It has an antiexudative effect. Dexamethasone effectively suppresses inflammatory processes.
The combination of glucocorticosteroids with antibiotics can reduce the risk of infection.
Indications:
Inflammatory conditions of the eye associated with superficial bacterial infection or risk of bacterial infection that respond to corticosteroids, such as:
– inflammation of the conjunctiva of the eyelid or eyeball;
– inflammation of the cornea and anterior segment of the eye;
– chronic uveitis of the anterior segment of the eye;
Method of administration and dosage:
Apply externally 1-2 drops in each eye, can be applied up to 6 times a day.
Contraindications:
Hypersensitivity to the components of the combination.
Precautions:
Do not exceed recommended doses. Use with caution in glaucoma and cataracts.
Side effects:
Local: Allergic reactions accompanied by itching and swelling of the eyelids, conjunctival hyperemia. Side effects caused by the steroid component: increased intraocular pressure with possible subsequent development of glaucoma, damage to the optic nerve and visual fields (if the drug is used for more than 10 days, intraocular pressure monitoring is necessary); posterior subcapsular cataract, delayed wound healing. Local use of steroids in diseases causing thinning of the cornea or sclera may lead to their perforation.
Secondary infection: The development of secondary infection is observed after the use of combination drugs containing GCS in combination with antibiotics.
Storage method:
Store at temperatures not exceeding 30 degrees.
Package:
The cardboard box contains a 5 ml plastic bottle and paper instructions.
