Description
Trade name:
Dexatobrin
Compound:
Each 1 ml of the preparation contains:
Tobramycin 0.3%
Dexamethasone 0.1%
Auxiliary components:
benzalkonium chloride, disodium edetate, sodium chloride, sodium sulfate anhydrous, tyloxapol, hydroxyethylcellulose, sodium hydroxide or sulfuric acid (to maintain pH), purified water.
Properties:
A combination drug with antibacterial and anti-inflammatory action for local use in ophthalmology.
Tobramycin is a broad-spectrum antibiotic from the aminoglycoside group. It is active against gram-positive and gram-negative microorganisms: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis /including strains resistant to penicillin/), Streptococcus spp. (including some beta-hemolytic species of group A, some non-hemolytic species and some strains of Streptococcus pneumoniae), Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, Proteus vulgaris, Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, as well as some strains of Neisseria spp.
Dexamethasone is a glucocorticosteroid. It has a pronounced anti-inflammatory, anti-allergic and desensitizing effect. It has an anti-exudative effect.
Indications:
– prevention of postoperative infectious complications;
-blepharitis;
-conjunctivitis;
-keratitis (without damage to the epithelium).
Method of administration and dosage:
Eye drops are instilled 1-2 drops into the conjunctival sac of the affected eye (or eyes) every 4-6 hours. In the first 24-48 hours, the dose can be increased to 1-2 drops into the conjunctival sac every 2 hours.
Contraindications:
– viral diseases of the cornea and conjunctiva (including keratitis caused by Herpes simplex, chickenpox);
-mycobacterial eye infection;
-fungal eye diseases;
– conditions after removal of a foreign body from the cornea;
– hypersensitivity to any component of the drug.
Precautions:
When prescribing Dexatobrin simultaneously with aminoglycoside antibiotics for systemic use, peripheral blood picture should be monitored.
When using Dexatobrin simultaneously with other eye drops or ointments, the interval between their applications should be at least 5 minutes.
The bottle must be closed after each use. Shake the bottle before use. When instilling, do not touch the tip of the dropper to the eye.
Side effects:
Allergic reactions: itching and swelling of the eyelids, redness of the conjunctiva.
From the organ of vision (caused by dexamethasone): increased intraocular pressure, formation of posterior subcapsular cataract, slowing of the wound healing process.
Others: development of secondary infection (including bacterial), as a consequence of suppression of the patient’s protective response. The appearance of non-healing ulcers on the cornea after long-term treatment with GCS may indicate the development of a fungal infection.
Storage method:
Store at a temperature not exceeding 27 degrees.
Package:
The cardboard box contains a 5 ml dropper bottle and paper instructions.
