Description
Trade name:
Alphanova Plus
Compound:
Each ml contains:
brimonidine tartrate 2 mg
timolol 5 mg
Auxiliary components:
Sodium chloride.
Properties:
Brimonidine is a selective alpha2-adrenergic agonist that has a stimulating effect on alpha2-adrenergic receptors. When used in the dosage form of 0.15% eye drops, the maximum decrease in intraocular pressure (IOP) is observed after 2 hours. The hypotensive effect of brimonidine develops due to the disruption of the formation of intraocular fluid and the improvement of its outflow along the uveoscleral pathway. Timolol is a non-selective beta-blocker. When used locally in ophthalmology, it reduces both normal and elevated intraocular pressure by reducing the formation of intraocular fluid and improving its outflow, does not affect accommodation and pupil size.
The maximum effect develops 1-2 hours after instillation into the eyes. The effect lasts up to 24 hours.
Indications:
-open-angle glaucoma;
-ophthalmic hypertension (in monotherapy or in combination with other drugs sensitive to IOP).
Method of administration and dosage:
Locally. In the conjunctival sac of the affected eye, 1 drop 3 times a day at intervals of about 8 hours.
Alfanova Plus can be used with other ophthalmic drugs to achieve IOP. If you use more than 2 types of eye drops, you must take a 5-minute break between their use.
Contraindications:
– hypersensitivity to brimonidine and other components of the drug;
– concomitant therapy with MAO inhibitors;
– children under 2 years of age, weight loss (up to 20 kg);
-breastfeeding period.
With caution:
– orthostatic hypotension, heart failure, cerebrovascular diseases leading to cerebral circulatory failure, renal failure (CC below 40 ml/min), liver failure, depression, Raynaud’s syndrome, thromboangiitis obliterans, children under 7 years of age.
Precautions:
Taking the drug Alfanova Plus may be accompanied by episodes of weakness and drowsiness in some patients. In the event that work is associated with monitoring dangerous objects, heights, driving vehicles, it is necessary to warn in advance about a possible decrease in attention and speed of psychomotor reactions, it is recommended to refrain from these types of activities.
Side effects:
From the visual organs: very often – allergic conjunctivitis, conjunctival hyperemia, itching of the mucous membrane of the eyes and skin of the eyelids; often – burning sensation, follicular conjunctivitis, allergic reactions of the eyes (including keratoconjunctivitis), blepharitis, blepharoconjunctivitis, impaired visual perception, cataract, conjunctival edema.
From the central nervous system: often – headache, drowsiness, insomnia, dizziness.
From the cardiovascular system: often – increased blood pressure; uncommon – decreased blood pressure.
From the respiratory system: often – bronchitis, cough, shortness of breath.
From the digestive tract: often – gastrointestinal disorders – dyspepsia, dryness of the oral mucosa.
From the skin and subcutaneous tissue: often – rash.
Infectious and parasitic diseases: often – flu-like syndrome, infectious disease (chills and respiratory infection), rhinitis, sinusitis, including contagious.
Laboratory findings: often – hypercholesterolemia.
Storage method:
Store at temperatures not exceeding 30 degrees.
Package:
The cardboard box contains a 5 ml dropper bottle and paper instructions.
