Description
Trade name:
Voltaren
Compound:
Each ampoule contains:
75 mg diclofenac sodium.
Auxiliary components:
benzyl alcohol, sodium disulfite, mannitol, sodium hydroxide, propylene glycol, water for injection.
Properties:
NSAID, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with the inhibition of COX activity – the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play an important role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through the suppression of prostaglandin synthesis) and central (due to the inhibition of prostaglandin synthesis in the central and peripheral nervous system).
Indications:
Inflammatory and degenerative diseases of the musculoskeletal system, including rheumatoid, juvenile, chronic arthritis; ankylosing spondylitis and other spondyloarthropathies; osteoarthrosis; gouty arthritis; bursitis, tendovaginitis; pain syndrome from the spine (lumbago, sciatica, ossalgia, neuralgia, myalgia, arthralgia, radiculitis); post-traumatic postoperative pain syndrome accompanied by inflammation (for example, in dentistry and orthopedics); algomenorrhea; inflammatory processes in the pelvis (including adnexitis); infectious and inflammatory diseases of the ENT organs with severe pain syndrome (as part of complex therapy): pharyngitis, tonsillitis, otitis.
Method of administration and dosage:
Administered deep intramuscularly. Single dose – 75 mg. If necessary, repeated administration is possible, but not earlier than after 12 hours.
The duration of use is no more than 2 days, if necessary, then switch to oral or rectal use of diclofenac.
The maximum daily dose is 150 mg.
Contraindications:
Hypersensitivity to diclofenac and excipients of the drug used; “aspirin triad” (attacks of bronchial asthma, urticaria and acute rhinitis when taking acetylsalicylic acid or other NSAIDs); erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; proctitis (only for suppositories); pregnancy (for intramuscular administration); third trimester of pregnancy (for oral and rectal administration); childhood and adolescence under 18 years of age (for intramuscular administration and for prolonged-release dosage forms).
Precautions:
Use with special caution in cases of liver, kidney, gastrointestinal diseases in the anamnesis, dyspeptic phenomena, bronchial asthma, arterial hypertension, heart failure, immediately after serious surgical interventions, as well as in elderly patients.
If there is a history of allergic reactions to NSAIDs and sulfites, diclofenac is used only in emergency cases. During treatment, systematic monitoring of liver and kidney function and peripheral blood picture is necessary.
Side effects:
From the digestive system: often – abdominal pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, decreased appetite, anorexia, increased activity of aminotransferases in the blood serum; rarely – gastritis, gastrointestinal bleeding, vomiting of blood, melena, diarrhea with blood, ulcers of the stomach and intestines (with or without bleeding or perforation), hepatitis, jaundice, liver dysfunction;
From the nervous system: often – headache, dizziness;
From the sensory organs: often – vertigo; very rarely – visual impairment (blurred vision), diplopia, hearing impairment, tinnitus, dysgeusia.
Dermatological reactions: often – skin rash.
Storage method:
In a dry, dark, cool place.
Package:
The cardboard box contains 6 ampoules of 3 ml each and paper instructions.
