Description
Trade name:
Bi-Ketogestic
Compound:
Each tablet contains:
Ketoprofen 150 mg
Auxiliary components:
Lactose monohydrate, microcrystalline cellulose, starch, magnesium stearate, sodium croscarmellose.
Properties:
NSAID. Has anti-inflammatory, analgesic and antipyretic effects. Ketoprofen blocks the action of COX-1 and COX-2 enzymes and partially lipoxygenase, which leads to the suppression of prostaglandin synthesis (including in the central nervous system, most likely in the hypothalamus).
Stabilizes liposomal membranes in vitro and in vivo, in high concentrations in vitro inhibits the synthesis of bradykinin and leukotrienes. Ketoprofen does not have a negative effect on the condition of articular cartilage.
Indications:
Method of administration and dosage:
Orally, during or after meals, 1 tablet (150 mg) 1 time per day.
During migraine, 300 mg per day can be taken in divided doses.
use the minimum effective dose for a practically achievable course.
Contraindications:
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, severe liver and/or kidney dysfunction. III trimester of pregnancy. Age up to 15 years.
Hypersensitivity to ketoprofen and salicylates.
Precautions:
Ketoprofen can be taken with milk or antacids to reduce the incidence of gastrointestinal upset. Antacids and milk do not affect the absorption of the drug.
During treatment, it is necessary to monitor the peripheral blood picture and the functional state of the liver and kidneys, especially in elderly patients.
Side effects:
From the digestive system: pain in the epigastric region, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, liver dysfunction, rarely – erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract.
From the central nervous system: headache, dizziness, tinnitus, drowsiness.
From the urinary system: impaired renal function.
Allergic reactions: skin rash, rarely – bronchospasm.
Storage method:
Store at temperatures not exceeding 30 degrees.
