Description
Trade name:
Klacid
Composition:
Each tablet contains:
Clarithromycin 250 mg
Excipients:
Croscarmellose sodium, microcrystalline cellulose, silicon dioxide, povidone, stearic acid, magnesium stearate, talc, hypromellose, hydroxypropyl cellulose, propylene glycol, titanium dioxide.
Properties:
A second-generation macrolide bacteriostatic antibiotic from the group of broad-spectrum macrolides. Disrupts the synthesis of microorganism proteins (binding the 50S subunit of the ribosome membrane of the microbial cell).
Indications:
– lower respiratory tract infections (bronchitis, pneumonia);
– upper respiratory tract infections (pharyngitis, sinusitis, otitis);
– skin and soft tissue infections (folliculitis, erysipelas);
– widespread or localized mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare;
– localized infections caused by Mycobacterium chelonae, Mycobacterium fortuitum and Mycobacterium kansasii;
– elimination of H. pylori and reduction in the frequency of duodenal ulcer recurrence.
Method of administration and dosage:
For adults, the average oral dose is 250 mg 2 times a day. If necessary, 500 mg 2 times a day can be prescribed. The duration of the course of treatment is 6-14 days.
For children, the drug is prescribed in syrup at a dose of 7.5 mg / kg of body weight / day. The duration of the course of treatment is 7-10 days.
Contraindications:
– when treating with clarithromycin, it is prohibited to take cisapride, pimozide, astemizole and terfenadine;
in patients taking these drugs simultaneously with clarithromycin, their concentration in the blood increases. In this case, the QT interval may be prolonged and cardiac arrhythmias may develop, including ventricular paroxysmal tachycardia, ventricular fibrillation, and ventricular flutter or fibrillation;
– severe liver and/or kidney dysfunction;
– hypersensitivity to macrolide antibiotics.
Precautions:
It is necessary to pay attention to the possibility of cross-resistance between clarithromycin and other macrolide antibiotics, as well as lincomycin and clindamycin.
With prolonged or repeated use of the drug, superinfection may develop.
Side effects:
The most common complaints from the digestive system are nausea, dyspepsia, abdominal pain, vomiting, and diarrhea.
There are reports of rare cases of hepatitis with increased levels of liver enzymes in the blood and the development of cholestasis and jaundice.
When taking clarithromycin orally, allergic reactions were observed, the intensity of which varied from urticaria and skin rash to anaphylaxis and Stevens-Johnson syndrome.
Isolated cases of thrombocytopenia and leukopenia are reported.
Storage:
Store at a temperature not exceeding 30 degrees.
Packaging:
A cardboard box contains 1 blister of 14 tablets and paper instructions.
