Description
Trade name:
Averozolid
Composition:
Each tablet contains:
Linezolid 600 mg
Excipients:
corn starch – 66 mg, microcrystalline cellulose – 97 mg, povidone K30 – 14 mg, sodium croscarmellose – 17 mg, magnesium stearate – 8 mg, colloidal silicon dioxide – 4 mg, calcium hydrogen phosphate – 40 mg, sodium lauryl sulfate – 4 mg.
Properties:
An antimicrobial agent, belongs to the class of oxazolidinones. The mechanism of action is due to the selective inhibition of protein synthesis in bacteria. By binding to bacterial ribosomes, linezolid prevents the formation of the functional initiation complex 70S, which is a component of the translation process during protein synthesis.
Indications:
Treatment of infectious and inflammatory diseases caused by susceptible anaerobic and aerobic gram-positive microorganisms (including infections accompanied by bacteremia): community-acquired pneumonia; hospital pneumonia; skin and soft tissue infections; infections caused by Enterococcus spp. (including strains of Enterococcus faecalis and Enterococcus faecium resistant to vancomycin). Infections caused by gram-negative microorganisms, confirmed or suspected (as part of combination therapy).
Method of administration and dosage:
The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.
On average, adults and children over 12 years of age take 600 mg every 12 hours, the duration of treatment is from 10 to 28 days
Children under 11 years of age take 10 mg / kg every 8 hours, the duration of treatment is from 10 to 28 days.
Contraindications:
Hypersensitivity to linezolid.
Precautions:
If diarrhea develops while using linezolid, the risk of developing pseudomembranous colitis of varying severity should be taken into account.
During treatment, it is necessary to conduct a clinical blood test in patients with an increased risk of bleeding, a history of myelosuppression, as well as with the simultaneous use of drugs that reduce hemoglobin levels, platelet count or their functional properties, as well as in patients receiving linezolid for more than 2 weeks.
Side effects:
From the digestive system: often – taste perversion, nausea, vomiting, diarrhea, abdominal pain (including spastic), flatulence, changes in total bilirubin, ALT, AST, alkaline phosphatase.
From the hematopoietic system: often – reversible anemia, thrombocytopenia, leukopenia, pancytopenia.
Others: often – headache, candidiasis; rarely – cases of peripheral neuropathy and optic neuropathy when used for more than 28 days (the relationship between the use of linezolid and the development of neuropathy has not been proven).
Adverse reactions do not depend on the dose and, as a rule, do not require discontinuation of treatment.
Storage method:
In a dry, cool place at a temperature not exceeding 30 degrees.
Packaging:
A cardboard box contains 1 blister of 10 tablets, paper instructions.
