Description
Trade name:
Flix
Composition:
Each dose of spray contains:
Fluticasone propionate 50 mcg
Excipients:
dextrose, avicel RC591 (microcrystalline cellulose, sodium carmellose), phenylethanol, benzalkonium chloride, polysorbate, hydrochloric acid, purified water.
Properties:
GCS for intranasal use. Has a pronounced anti-inflammatory effect. With intranasal administration, there is no systemic effect, practically does not inhibit the hypothalamic-pituitary-adrenal system.
The anti-inflammatory effect of fluticasone propionate is realized as a result of its interaction with glucocorticoid receptors. Suppresses the proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils. Fluticasone propionate reduces the production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phases of an allergic reaction. It has a rapid anti-inflammatory effect on the nasal mucosa. The antiallergic effect appears within 2-4 hours after the first application. Reduces sneezing, itching in the nose, rhinorrhea, nasal congestion, discomfort in the paranasal sinuses and a feeling of pressure around the nose and eyes. In addition, it relieves eye symptoms associated with allergic rhinitis.
Indications:
Treatment of year-round and seasonal allergic rhinitis, including pollinosis (hay fever): -pain, feeling of pressure in the paranasal sinuses; -nasal congestion, sneezing, itching in the nose; -lacrimation.
Method of administration and dosage:
Adults and children over 12 years old:
1st week: 2 sprays in each nostril once a day (200 mcg/day);
from the 2nd week to 3 months: 1 or 2 sprays in each nostril once a day (100-200 mcg/day).
The maximum daily dose is 200 mcg/day (no more than 2 sprays in each nostril).
The maximum course of treatment is 3 months per year.
Children aged 4 to 12 years:
1 spray in each nostril once a day (100 mcg/day). The recommended dose (100 mcg/day) should not be exceeded. In children aged 4 to 12 years, the drug should be used for the shortest possible period of time necessary to achieve control over the symptoms of the disease. It is necessary to consult the attending physician if the child needs to use the drug for a period of time exceeding 2 months per year.
The maximum daily dose is 100 mcg (no more than 1 spray and each nostril).
Contraindications:
-hypersensitivity to fluticasone propionate and other components of the drug;
-children under 4 years of age;
-recently suffered nasal injury or surgery and nasal cavity.
Precautions:
Before using the drug, the patient should consult a doctor in the following cases:
-taking drugs for the treatment of HIV infection, such as ritonavir;
-taking GCS for the treatment of bronchial asthma, allergies, skin rashes;
-taking drugs for the treatment of fungal infections, such as ketoconazole;
-taking other potent inhibitors of the CYP3A isoenzyme, such as itraconazole;
in the presence of glaucoma or cataracts.
Take with caution in the presence of an infection of the nasal cavity or paranasal sinuses. It should be taken into account that infectious diseases of the nose require appropriate treatment, but are not a contraindication to the use of Flix® nasal spray.
Side effects:
From the nervous system: often – headache, a feeling of unpleasant taste and smell. The occurrence of headache, a feeling of unpleasant taste and smell has also been reported with the use of other nasal sprays.
From the respiratory system: very often – nosebleed; often – dryness of the mucous membrane in the nasal cavity and pharynx, irritation of the mucous membrane in the nasal cavity and pharynx (these adverse reactions, as well as nosebleeds, were also observed when using other intranasal .
Storage method:
In a cool, dry place at a temperature not exceeding 30 degrees.
Packaging:
A cardboard box contains a 20 ml bottle with a dispenser, paper instructions.
