Description
Tradename:
Levohistam
Compound:
Each tablet contains:
Levocetirizine dihydrochloride.
Auxiliary components:
microcrystalline cellulose, croscarmellose sodium, pregelatinized starch, colloidal silicon dioxide, magnesium stearate.
Properties:
Levocetirizine is the R-enantiomer of cetirizine; competitive histamine antagonist; blocks histamine H1 receptors, the affinity for which is 2 times higher than that of cetirizine. Levocetirizine has an effect on the histamine-dependent stage of allergic reactions; reduces the migration of eosinophils, reduces vascular permeability, limits the release of inflammatory mediators. Prevents the development and facilitates the course of allergic reactions, has an antiexudative, antipruritic effect; has virtually no anticholinergic and antiserotonin effects. In therapeutic doses it has virtually no sedative effect.
Indications:
Treatment of symptoms of year-round (persistent) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, nasal congestion, rhinorrhea, lacrimation, conjunctival hyperemia;
hay fever (hay fever);
hives;
other allergic dermatoses, accompanied by itching and rashes.
Directions for use and dosage:
The drug is taken orally during meals or on an empty stomach, without chewing, with a small amount of water. It is recommended to take the daily dose in 1 dose.
Adults and children over 6 years of age: the daily dose is 5 mg. The maximum daily dose is 5 mg.
Tablets are not prescribed for children under 6 years of age: for them, a different, liquid dosage form is used.
Contraindications:
Hypersensitivity to the active substance, cetirizine, hydroxyzine, any piperazine derivative or any other excipient of the drug;
lactase deficiency, lactose intolerance, glucose-galactose malabsorption; end-stage renal failure, children under 6 years of age (for tablets, due to limited data on effectiveness and safety).
Carefully:
Caution is required in the following conditions: chronic renal failure (correction of the dosage regimen is necessary); in elderly patients (with an age-related decrease in glomerular filtration), with simultaneous use of alcohol, prostatic hyperplasia, as well as in the presence of other predisposing factors to urinary retention, since levocetirizine may increase the risk of urinary retention; when prescribed to pregnant women and during breastfeeding.
Precautionary measures:
Levocetirizine may cause increased drowsiness; therefore, the drug may affect the ability to drive a car or operate machinery. While taking Levocetirizine, it is advisable to refrain from performing potentially hazardous types of work that require increased concentration and speed of psychomotor reaction (including driving a car and operating machinery).
Side effects:
From the immune system: hypersensitivity reactions, including anaphylaxis.
Metabolism: increased appetite.
From the mental side: anxiety, aggression, agitation, depression, hallucinations, insomnia, suicidal thoughts.
From the nervous system: convulsions, thrombosis of the dural sinuses, paresthesia, dizziness, fainting, tremor, dysgeusia.
From the organ of hearing: vertigo.
From the organ of vision: blurred vision, blurred vision, inflammatory manifestations.
From the cardiovascular system: angina pectoris, tachycardia, palpitations, jugular vein thrombosis.
From the respiratory system: shortness of breath, increased symptoms of rhinitis.
From the digestive system: nausea, vomiting, diarrhea.
Hepatobiliary disorders: hepatitis, changes in liver function tests.
From the urinary system: dysuria, urinary retention.
From the skin and soft tissues: angioedema, persistent drug erythema, itching, rash, urticaria, hypotrichosis, fissures, photosensitivity.
From the musculoskeletal system: muscle pain, arthralgia.
General disorders: peripheral edema, weight gain.
Other: cross-reactivity.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Storage method:
Store out of reach of children, in a dark place, at a temperature not exceeding 25 degrees.
