Description
Tradename:
Xilone forte
Compound:
Every 5 ml of syrup contains:
Prednisolone 15 mg
Auxiliary components:
Sodium dihydrogen polysorbitol, disodium edetate, methyl dihydroxybenzoate, sorbitol, raspberry flavor, purified water.
Properties:
Prednisolone is a synthetic glucocorticoid drug, a dehydrated analogue of hydrocortisone. It has anti-inflammatory, anti-allergic, immunosuppressive, anti-shock effects, increases the sensitivity of adrenergic receptors to endogenous catecholamines.
Indications:
Systemic connective tissue diseases:
– systemic lupus erythematosus; scleroderma; periarteritis nodosa; dermatomyositis; rheumatoid arthritis.
Acute and chronic inflammatory diseases of the joints:
– gouty and psoriatic arthritis; osteoarthritis (including post-traumatic); polyarthritis; glenohumeral periarthritis; ankylosing spondylitis (ankylosing spondylitis); rheumatoid arthritis, including juvenile rheumatoid arthritis; Still’s syndrome in adults; bursitis; nonspecific tenosynovitis; synovitis; epicondylitis.
Acute rheumatism, acute rheumatic carditis.
Bronchial asthma.
Acute and chronic allergic diseases, including:
– allergic reactions to medications and food products; serum sickness; hives; allergic rhinitis; drug exanthema; hay fever, etc.
Skin diseases:
-pemphigus; psoriasis; eczema; atopic dermatitis (common neurodermatitis); contact dermatitis (affecting a large surface of the skin); toxicoderma; seborrheic dermatitis; exfoliative dermatitis; toxic epidermal necrolysis (Lyell’s syndrome); bullous dermatitis herpetiformis; Stevens-Johnson syndrome.
Cerebral edema (only after symptoms of increased intracranial pressure are confirmed by magnetic resonance or computed tomography) due to a brain tumor and/or associated with surgery or radiation therapy, after parenteral use of prednisolone.
Allergic eye diseases:
– allergic forms of conjunctivitis.
Inflammatory eye diseases:
-sympathetic ophthalmia; severe sluggish anterior and posterior uveitis; Optic neuritis.
Primary or secondary adrenal insufficiency (including the condition after removal of the adrenal glands). The drugs of choice are hydrocortisone or cortisone; if necessary, synthetic analogues can be used in combination with mineralocorticosteroids; The addition of mineralocorticosteroids is especially important in children.
Congenital adrenal hyperplasia.
Kidney diseases of autoimmune origin (including acute glomerulonephritis); nephrotic syndrome (including against the background of lipoid nephrosis).
Subacute thyroiditis.
Diseases of the blood and hematopoietic system: agranulocytosis; panmyelopathy; autoimmune hemolytic anemia; lympho- and myeloid leukemia; lymphogranulomatosis; thrombocytopenic purpura; secondary thrombocytopenia in adults; erythroblastopenia (erythrocyte anemia); congenital (erythroid) hypoplastic anemia.
Interstitial lung diseases: acute alveolitis; pulmonary fibrosis; sarcoidosis stage II-III.
Tuberculous meningitis, pulmonary tuberculosis, aspiration pneumonia (in combination with specific chemotherapy).
Berylliosis, Loeffler’s syndrome (not amenable to other therapy), lung cancer (in combination with cytostatics).
Multiple sclerosis.
Gastrointestinal diseases:
ulcerative colitis; Crohn’s disease; local enteritis.
Hepatitis.
Prevention of graft rejection during organ transplantation. Hypercalcemia due to cancer.
Multiple myeloma.
Directions for use and dosage:
The drug is taken orally.
The dose and duration of treatment are selected by the doctor individually, depending on the indications and severity of the disease. The selection of the dose and duration of treatment is determined depending on the individual response to therapy.
It is recommended to take the entire daily dose of the drug once or a double daily dose – every other day, taking into account the circadian rhythm of endogenous secretion of GCS in the interval from 6 to 8 am. The daily dose of the drug should be taken after meals (breakfast). A high daily dose can be divided into 2-4 doses, with a larger dose taken in the morning.
In acute conditions and as replacement therapy for adults, an initial dose of 20-30 mg/day is prescribed, the maintenance dose is 5-10 mg/day. If necessary, the initial dose can be 15-100 mg/day, maintaining 5-15 mg/day.
For children aged 3 years and older, the initial dose is 1-2 mg/kg body weight per day in 4-6 doses, maintenance – 0.3-0. 6 mg/kg/day.
Contraindications:
– hypersensitivity to prednisolone or any of the excipients;
– lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
-systemic mycosis;
-simultaneous use of live and attenuated vaccines with immunosuppressive doses of the drug;
-eye infection caused by the herpes simplex virus (due to the risk of perforation
