Description
Tradename:
Melacryst
Compound:
Each oral soluble film contains:
Melatonin 1.5 mg
Auxiliary components:
Polyvinyl alcohol, polyethylene glycol, starch, glycerol, menthol, blueberry flavor, simethicone.
Properties:
A synthetic analogue of the pineal body (epiphysis) hormone melatonin.
It has an adaptogenic, sedative and hypnotic effect.
Normalizes circadian rhythms. Increases the concentration of GABA and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase involved in the synthesis of GABA, dopamine and serotonin. It is known that GABA is an inhibitory mediator in the central nervous system, and a decrease in the activity of serotonergic mechanisms may be important in the pathogenesis of depressive conditions and disorders.
Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the intellectual and mnestic functions of the brain, on the emotional and personal sphere. Helps organize biological rhythm and normalize night sleep. Improves sleep quality, reduces the frequency of headaches, dizziness, and improves mood. Accelerates falling asleep, reduces the frequency of night awakenings, improves well-being after waking up in the morning, and does not cause a feeling of lethargy, weakness and fatigue when waking up. Makes dreams more vivid and emotionally rich.
Indications:
For sleep disorders, incl. caused by a disturbance in the sleep-wake rhythm, such as desynchronosis (sudden change of time zones).
Directions for use and dosage:
The optimal dosage regimen is determined by the doctor. The compliance of the dosage form of a particular drug with the indications for use and dosage regimen should be strictly observed.
Individual. Apply an oral soluble film to the tongue at a dose of 1.5 mg 1 time per day 30-40 minutes before bedtime.
Contraindications:
Increased sensitivity to melatonin; severe renal impairment (creatinine clearance <30 ml/min), autoimmune diseases (no clinical data), liver failure, pregnancy, breastfeeding, age under 18 years (efficacy and safety have not been established).
With caution: renal failure (creatinine clearance >30 ml/min), old age.
Precautionary measures:
It is recommended to avoid exposure to bright light while using melatonin.
It is necessary to inform women planning pregnancy that melatonin has a weak contraceptive effect.
While using melatonin, you should not drink alcohol, which reduces its effectiveness.
Side effects:
From the hematopoietic system: rarely – leukopenia, thrombocytopenia.
From the immune system: frequency unknown – hypersensitivity reactions.
From the side of metabolism: rarely – hypertriglyceridemia, hypokalemia, hyponatremia.
Storage method:
Store at a temperature not exceeding 30 degrees.
