Description
Trade name:
Miconaz
Compound:
Every 100 grams of gel contains:
Miconazole 2 g
Auxiliary components:
70% sorbitol solution, glycerin, sodium carboxymethylcellulose, sodium benzoate, orange oil, citric acid monohydrate, polysorbate 80, purified water.
Properties:
Miconazole is an imidazole antifungal agent with fungicidal and bactericidal activity against dimorphic fungi, dermatophytes and Candida species including Candida albicans, Dimorphons fungi, Cryptococcus neoformans, Pityrosporum sp, Torulopsis glabrata and some gram-positive bacilli and cocci. Accordingly, Miconazole gel is effective in the treatment of oral and gastrointestinal infections, particularly those caused by Candida albicans. At low concentrations, miconazole nitrate interacts with fungal cytochrome P-450, which affects the suppression of the demethylation step in ergosterol biosynthesis. Depletion of ergosterol and concomitant accumulation of lanosterol lead to changes in a number of membrane-related functions. At high concentrations, miconazole interacts with membrane lipids, causing direct destruction of membrane lipids and subsequent leakage of the fungal cell contents. In Candida albicans, miconazole ultimately inhibits blastospores into the invasive mycelial form.
Indications:
Prevention and treatment of oral and pharyngeal candidiasis of various etiologies in children and adults, in particular after treatment with antibiotics, corticosteroids, after radiotherapy and chemotherapy and in immunodeficiency states.
Method of administration and dosage:
The drug is recommended to be applied after meals. For infants: 1/4 teaspoon 4 times a day.
For children over two years of age and adults: 1/2 teaspoon 4 times a day.
The drug should be kept in the mouth as long as possible. The course of treatment is 7-14 days.
Contraindications:
– hypersensitivity to the ingredients of the drug
– liver or kidney failure and congenital liver dysfunction.
Precautions:
The use of the drug during pregnancy and lactation is possible if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Side effects:
The following adverse reactions have been reported following oral administration of miconazole:
– from the gastrointestinal tract: nausea, vomiting and very rarely diarrhea (usually with long-term treatment).
– from the immune system (very rare): allergic conditions, including angioedema and anaphylactic reactions; Lyell’s syndrome, Stevens-Johnson syndrome, urticaria, rash.
– from the liver and biliary tract (very rare): hepatitis (isolated cases)
Storage method:
Store at temperatures not exceeding 30 degrees.
Package:
The cardboard box contains a 20 gram tube and paper instructions.
